Immunological competence of T and B lymphocytes in clophosphamide-induced tolerance

Autor:	I. A. Kondrat'eva, L. A. Pevnitskii, L. N. Fontalin, T. K. Novikova
Rok vydání:	1976
Předmět:	B-1 cell Interleukin 21 ZAP70 Immunology Lymphokine Cytotoxic T cell General Medicine IL-2 receptor Biology Natural killer T cell Antigen-presenting cell General Biochemistry Genetics and Molecular Biology
Zdroj:	Bulletin of Experimental Biology and Medicine. 81:548-551
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00797566
Popis:	Immunological competence of T and B lymphocytes of mice was studied 7 days after induction of tolerance by injection of a massive dose of sheep's red cells and cyclophosphamide. The ability of lymphocytes of the tolerant mice to influence cooperation between normal T and B lymphocytes also was investigated. This particular form of tolerance was shown to be due not to suppressor T cells, but to a true deficiency of “helper” T cells (in both the thymus and spleen) and, to some extent also, of B cells (in the spleen). The very small deficiency of B cells in the bone marrow was connected with the nonspecific action of cyclophosphamide. It is postulated that cyclophosphamide selectively eliminates cells proliferating under the influence of the antigen.
Databáze:	OpenAIRE
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