A widely applicable automated sampling apparatus for dissolution testing

Autor:	B.G Snider, Ronald A. Hill
Rok vydání:	1987
Předmět:	Inert Flexibility (engineering) Piston pump business.industry Chemistry Controller (computing) Pharmaceutical Science Mineralogy Sampling (statistics) Filter (video) Drug release Dissolution testing Process engineering business
Zdroj:	International Journal of Pharmaceutics. 36:175-183
ISSN:	0378-5173
DOI:	10.1016/0378-5173(87)90153-0
Popis:	An automated sampling apparatus for drug release testing is described that is chemically inert and can filter particulates larger than 0.2 μm. Samples are pushed through filters with inert piston pumps capable of delivering up to 100 psi, so that small-pore membrane filters can be reliably used. These filters are now available in a variety of materials and pore sizes so that in every case a filter was identified that could remove undissolved drug and excipients while avoiding excessive adsorption. A PC-based controller provides flexibility, ease of use, and operation of multiple units. The system proved applicable with heavy particulate loading and for several hydrophobic drugs. Important considerations in designing an automated system are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5f1f1eb5fb0d9dffbb514957f87303be https://doi.org/10.1016/0378-5173(87)90153-0 Zobrazit plný text záznamu