Use of Myoglobin as a Marker and Predictor in Myoglobinuric Acute Kidney Injury
| Autor: | Janko Kovač, Vladimir Premru, Rafael Ponikvar |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Creatinine biology business.industry medicine.medical_treatment Incidence (epidemiology) Acute kidney injury Hematology urologic and male genital diseases medicine.disease Gastroenterology Group B Surgery chemistry.chemical_compound chemistry Myoglobin Nephrology Internal medicine medicine biology.protein Creatine kinase Hemodialysis business Rhabdomyolysis |
| Zdroj: | Therapeutic Apheresis and Dialysis. 17:391-395 |
| ISSN: | 1744-9979 |
| DOI: | 10.1111/1744-9987.12084 |
| Popis: | Serum creatine kinase (CK) is routinely used as a marker in the assessment of rhabdomyolysis and acute myoglobinuric kidney injury (Mb-AKI), while the use of myoglobin is much less explored in this respect. We retrospectively analyzed the incidence of Mb-AKI (creatinine [Cr] > 200 μmol/L) and the need for hemodialysis (HD) in 484 patients (70.5% males) with suspected rhabdomyolysis, grouped according to peak serum myoglobin (A: 1-5 mg/L, B: 5-15 mg/L, C: >15 mg/L). The median peak myoglobin was 7163 μg/L. Both peak Cr and peak CK were significantly higher in group C. The incidence of Mb-AKI was 24.6% in group A, 38.6% in group B (P 20 mg/L. Creatine kinase correlated with the severity of rhabdomyolysis, but less so with Mb-AKI. The peak Cr levels were not significantly different between patients divided by CK 60 μkat/L, or grouped into CK tertiles or quartiles. A significant proportion of patients with rhabdomyolysis experienced Mb-AKI, whose frequency increased in parallel with myoglobin levels. Myoglobin levels above 15 mg/L were most significantly related to the development of AKI and the need for HD. Blood myoglobin could serve as a valuable early predictor and marker of rhabdomyolysis and Mb-AKI. |
| Databáze: | OpenAIRE |
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