Effect of Extract of Adrenal Cortex upon Thymic Weight and Resistance to Bacterial Intoxication in Chronic Adrenal Insufficiency

Autor:	W. J. Merle Scott, W. L. Bradford
Rok vydání:	1931
Předmět:	medicine.medical_specialty Endocrinology medicine.anatomical_structure business.industry Adrenal cortex Internal medicine Both adrenal glands medicine Adrenal insufficiency medicine.disease business General Biochemistry Genetics and Molecular Biology Muscle hypertrophy
Zdroj:	Experimental Biology and Medicine. 28:428-431
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-28-5349
Popis:	Extirpation of both adrenal glands is rapidly fatal in most laboratory animals. However this operation seems to have little effect for several weeks upon the physical condition of the majority of rats submitted to it. But such apparently healthy survivors manifest at least 2 important differences from normal rats, an increased susceptibility to bacterial intoxication,1 and hypertrophy of the thymus.2 In each instance the variation has been correlated with a functional deficiency of the adrenal cortex rather than of the medulla.It is our purpose to report the effect of an extract of the adrenal cortex upon this chronic type of adrenal insufficiency, using as criteria the resistance of the animals to bacterial intoxication and the size of the thymus.Fifty-eight rats from 5 litters born on the same day were used. These were divided into 3 groups and sampled for the different groups according to the method adopted by Dr. Luce Clausen,3 insuring equal distribution of weight and equal representation of the diff...
Databáze:	OpenAIRE
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