3 Intrasound Therapy Reverses The Effects Of Alcohol Consumption On The Healing Tendon And Augments Healing
| Autor: | Olufunke O. Dosumu, F.I.O. Duru, A I Aiyegbusi, Adegoke M Akinfeleye, Charles C. Anunobi, Titilola Samuel |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Achilles tendon business.industry Population Connective tissue Physical Therapy Sports Therapy and Rehabilitation Histology General Medicine medicine.disease Tendon Surgery medicine.anatomical_structure Anesthesia Crush injury medicine Orthopedics and Sports Medicine Complication education business Alcohol consumption |
| Zdroj: | British Journal of Sports Medicine. 48:A2-A3 |
| ISSN: | 1473-0480 0306-3674 |
| DOI: | 10.1136/bjsports-2014-094114.3 |
| Popis: | Functional abnormalities in wound structure has been identified as a potential complication if a patient consumes alcohol prior to injury and studies suggest that even a single incidence of acute ethanol exposure can perturb the tissue response to trauma significantly. Ethanol ingestion has been shown to result in delayed and abnormal tendon healing 3 weeks after injury. This study investigated the effects of low intensity intrasound therapy (LITR) given twice daily on the morphology and antioxidant parameters in the healing tendon following an acute injury in rats exposed to prior ethanol consumption. Fifteen male rats, randomised into three groups all underwent induced crush injury to the Achilles tendon. Groups 2 and 3 had prior administration of 30% ethanol for six days. The three groups were allocated to: serve as controls (Group 1), received no treatment (Group 2), LITR twice daily (Group 3). LITR was commenced immediately post-injury and was given twice daily over the first 6 days. The animals were sacrificed on day 20 post-injury and the tendons were excised, and processed for histology and anti-oxidant and MDA assay. The tendons in group 2 showed disordered and haphazard collagen formation with neutrophilic infiltrates and high tenoblast population at 20 days post-injury while the LITR treated tendon had dense, well-ordered, parallel collagen deposits with fewer tenoblasts. LITR also significantly improved the antioxidant parameters and lowered the MDA compared with the alcohol-exposed untreated tendon (p LIRT thus reverses the deleterious effect of ethanol on the healing tendon and resulted in near-normal morphology of the healing tendon 20 days post-injury. References Aiyegbusi et al . Connective Tissue Research. 2012;53(6):478–484 Novasonic. www.novasonicwest.com/novasonic. 2007 Molina et al . Alcohol Clin Exp Res. 2002;26(1):120–8 Sommers MS. Crit Care Nurse . 1994;14:82–86, 88–93 |
| Databáze: | OpenAIRE |
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