| Popis: |
Our understanding of the development and mechanism(s) of allergic diseases has changed dramatically over the last 20 years. With the advent of genetic studies it has now become clear that the linear model, as defined by the allergic march, is no longer tenable. Instead, we must consider all allergies as complex multi-compartment models in which genes which control IgE production and also genes which govern other aspects of allergic disease, such as epithelium integrity, both play an important role. To explore such possibilities, this chapter asks four questions |
