Characterization of the roles of suppressor of cytokine signaling-3 in prostate cancer development and progression

Autor:	Jing Chen, Yu Fu, Jiaquan Xiao, Xiaoyu Qian, Ligang Ren, Kaisen Liao, Xian Fu
Rok vydání:	2015
Předmět:	biology Suppressor of cytokine signaling 1 business.industry medicine.medical_treatment General Medicine medicine.disease Suppressor of cytokine signalling Prostate cancer Cytokine Oncology Immunology otorhinolaryngologic diseases Cancer research medicine biology.protein SOCS3 Signal transduction business Interleukin 6 SOCS2
Zdroj:	Asia-Pacific Journal of Clinical Oncology. 11:106-113
ISSN:	1743-7555
DOI:	10.1111/ajco.12357
Popis:	As negative feedback regulators of cytokine signaling, suppressor of cytokine signaling proteins are induced by interleukins and various peptide hormones and may prevent sustained activation of signaling pathways. In particular, suppressor of cytokine signaling-3 (SOCS-3) plays pivotal roles in the development and progression of various cancers and exerts pleiotropic effects on cell proliferation and apoptosis. In recent years, abnormal expression of SOCS-3 and its multiple functions have been extensively investigated in human carcinomas, particularly in prostate cancer. SOCS-3 can act as an oncogene or a tumor suppressor depending on the cellular context. In this review, we focus on the role of SOCS-3 in prostate cancer development and prognosis, as well as the potential of SOCS-3 as a therapeutic target and diagnostic marker.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5f0a8b9ef93230f4b542a74812b930dc https://doi.org/10.1111/ajco.12357 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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