On-line purification and carbon-13 isotopic analysis of carbon dioxide in breath: evaluation of on-line gas chromatography-isotope ratio mass spectrometry
| Autor: | Sylvie Normand, F. Billion-Rey, E.J. Jumeau, J.L. Brazier, R. Guilluy, Jean-Paul Riou, Christiane Pachiaudi |
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| Rok vydání: | 1992 |
| Předmět: |
Chromatography
Isotope Chemistry Carbon-13 Analytical chemistry Mass spectrometry Biochemistry Analytical Chemistry chemistry.chemical_compound Carbon dioxide Environmental Chemistry Gas chromatography Gas chromatography–mass spectrometry Isotope-ratio mass spectrometry Spectroscopy Isotope analysis |
| Zdroj: | Analytica Chimica Acta. 259:193-202 |
| ISSN: | 0003-2670 |
| DOI: | 10.1016/0003-2670(92)85368-g |
| Popis: | An on-line gas chromatographic-isotope ratio mass spectrometric (IRMS) device consisting of a gas chromatograph, a column switching system, a continuous-flow dual inlet and an isotope ratio mass spectrometer is described. This device has been found suitable for the simultaneous on-line purification of expired breath CO2 and the determination of its isotopic composition. The quality of the analytical data obtained validated the clinical use of the method to perform breath tests at low enrichment levels and from small samples. The whole procedure is reliable, simple and efficient. It is capable of analysing breath samples down to 50 μ1 within 150 s. Its high reliability and advantages over the conventional IRMS technique are discussed. |
| Databáze: | OpenAIRE |
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