METABOLIC CHANGES IN HUMANS UPON LONG-TERM CONTAINMENT IN AN ARGON-BASED HYPOXIC GAS MIXTURE
| Autor: | N. V. Kochubeychik, V. S. Petrov, A. O. Ivanov, A. Yu. Yeroshenko, A. A. Ivanov, E. N. Bezkishkiy |
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| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Marine Medicine. 4:7-14 |
| ISSN: | 2587-7828 2413-5747 |
| DOI: | 10.22328/2413-5747-2018-4-2-7-14 |
| Popis: | The objective of the present study was an in-depth assessment of the main human metabolic parameters upon longterm (60 days) containment in a normobaric argon-based hypoxic gas mixture (AHGM) for checking the possibility to develop gas media able to reduce the risk of ignitions and fires in inhabited sealed objects, such as submarines. Study group included six male subjects aged 20 to 51 years and found to be fit for sea trips lasting for up to 90 days. Continuing containment in the test medium comprising 30–35% V/V argon, 13,3–14,5% V/V oxygen, and up to 0,8% V/V, the rest being nitrogen, lasted for 60 days. During this time the subject were engaged in typical physical activities and operator routines. Venous blood samples were taken before, every 15 days in the course of, and 5 days after containment. This regimen has been found to be associated with the gradual accumulation of under-oxidized products of carbohydrate, protein and cholesterol metabolism in the blood and with increasing atherogenicity index. Adaptation to this regimen was manifested as decreases in the magnitudes of the above changes suggesting that metabolism may be tuned to increase body tolerance to hypoxia. Within 5 days after containment, virtually complete normalization of parameters studied was observed. The data confirm that it is possible to make gas mixtures for improving fire safety of inhabited sealed objects, in particular submarines. |
| Databáze: | OpenAIRE |
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