Chiral salen-metal complexes as novel catalysts for asymmetric phase transfer alkylations

Autor:	Viktor Maleev, Michael North, Nikolai S. Ikonnikov, Yuri N. Belokon, Pavel Krasik, Vadim S. Kublitski
Rok vydání:	1999
Předmět:	chemistry.chemical_classification Aldimine Organic Chemistry Alkylation Biochemistry Toluene Medicinal chemistry Catalysis Metal chemistry.chemical_compound chemistry Sodium hydroxide visual_art Drug Discovery visual_art.visual_art_medium Organic chemistry Enantiomer Alkyl
Zdroj:	Tetrahedron Letters. 40:6105-6108
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(99)01214-9
Popis:	Chiral, salen-metal complexes have been tested as catalysts for the C -alkylation of aldimine Schiff's bases of alanine esters with alkyl bromides under phase-transfer conditions (solid sodium hydroxide, toluene, ambient temperature, 1–10% of the catalyst). The best catalyst, which was derived from a Cu(II) complex of (1 R ,2 R or 1 S ,2 S )-[ N,N′ -bis(2′-hydroxybenzylidene)]-1,2-diaminocyclohexane, gave α-methyl-α-amino acids with enantiomeric excesses of 70–96%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5efe4533a4fcbacaf05482e00ec0a3b2 https://doi.org/10.1016/s0040-4039(99)01214-9 Zobrazit plný text záznamu Full Text from ScienceDirect