Highly Filled Compositions Based on Alginate Gel and Fine Tricalcium Phosphate for 3D Printing of Tissue-Engineered Matrices
| Autor: | A. V. Mironov, O. A. Mironova, Vladimir K. Popov, T. Kh. Fatkhudinov, Evgeniya Kananykhina, Igor V. Smirnov, A. O. Mariyanats, Vladimir S. Komlev |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
010302 applied physics
Tissue engineered Materials science Composite number technology industry and agriculture General Engineering chemistry.chemical_element macromolecular substances 02 engineering and technology Calcium 021001 nanoscience & nanotechnology Phosphate 01 natural sciences Bone tissue engineering chemistry.chemical_compound chemistry Chemical engineering Phase (matter) 0103 physical sciences General Materials Science Alginate hydrogel 0210 nano-technology Elastic modulus |
| Zdroj: | Inorganic Materials: Applied Research. 11:1137-1143 |
| ISSN: | 2075-115X 2075-1133 |
| DOI: | 10.1134/s2075113320050214 |
| Popis: | In order to obtain hydrogel matrices for bone tissue engineering, the process of formation of highly filled alginate-calcium phosphate structures by 3D printing was developed. Optimal conditions for the formation of three-dimensional structures from Ca2+ crosslinked alginate hydrogels and highly filled alginate compositions with fine (5–30 μm) α-tricalcium phosphate (TCP) were determined. Comparative analysis of physicomechanical properties of crosslinked alginate hydrogels showed lower strength and higher elastic modulus of the TCP-filled composite in comparison with pure hydrogel. The difference between the mechanical characteristics of the filled and pure gels increases with the crosslinking density. It was found that, because of the significant content of the mineral dispersed phase, the α-TCP-filled hydrogel does not shrink during crosslinking, unlike pure alginate hydrogel. Using cultures of human umbilical cord mesenchymal stem cells, it was shown in vitro that all the studied samples of both pure and highly filled composite alginate matrices with α-TCP do not have short-term cytotoxic effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink