High-Resolution Bacterial Cytological Profiling Reveals Intrapopulation Morphological Variations upon Antibiotic Exposure

Autor:	Thanadon Samernate, Htut Htut Htoo, Joseph Sugie, Warinthorn Chavasiri, Joe Pogliano, Vorrapon Chaikeeratisak, Poochit Nonejuie
Rok vydání:	2023
Předmět:	Pharmacology Infectious Diseases Pharmacology (medical)
Zdroj:	Antimicrobial Agents and Chemotherapy. 67
ISSN:	1098-6596 0066-4804
DOI:	10.1128/aac.01307-22
Popis:	Phenotypic heterogeneity is crucial to bacterial survival and could provide insights into the mechanism of action (MOA) of antibiotics, especially those with polypharmacological actions. Although phenotypic changes among individual cells could be detected by existing profiling methods, due to the data complexity, only population average data were commonly used, thereby overlooking the heterogeneity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5eed2e6de0671bd143c9a1e3cbc8aa23 https://doi.org/10.1128/aac.01307-22 Zobrazit plný text záznamu