| Popis: |
Furosemide is a potent diuretic used for treatment of edema, hypertension and renal disease, among others. In this work, a simple and accurate method using 1H NMR has been developed for quantification of furosemide in pharmaceutical formulations. All evaluated parameters (selectivity, linearity, accuracy, precision, limit of detection and limit of quantification) showed satisfactory results. Five pharmaceutical formulations (tablets) were analyzed by the developed method and the method described in the Brazilian Pharmacopoeia. Results show no significant differences between them. Thus, furosemide quantification by NMR technique proved to be a promising method as an alternative for assessing the quality of medicines. |
