Invasive micropapillary carcinoma of the urinary bladder: An immunohistochemical study of neoplastic and stromal cells
| Autor: | Naoto Kuroda, Masato Tamura, Masahiko Ohara, Eriko Miyazaki, Takashi Hirouchi, Keiko Mizuno |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Pathology Urinary bladder Stromal cell medicine.diagnostic_test biology business.industry Urology medicine.medical_treatment Cystoscopy medicine.disease Glandular Differentiation Cystectomy medicine.anatomical_structure Carcinoembryonic antigen medicine Carcinoma biology.protein Immunohistochemistry business |
| Zdroj: | International Journal of Urology. 13:1015-1018 |
| ISSN: | 0919-8172 |
| DOI: | 10.1111/j.1442-2042.2006.01464.x |
| Popis: | A 66-year-old man complained of hematuria. A cystoscopy revealed a non-papillary tumor and radical cystectomy was performed. Macroscopically, an ulcerative lesion was observed. Microscopically, the neoplasm showed a mixture of urothelial carcinoma, squamous cell carcinoma and micropapillary carcinoma. Immunohistochemically, micropapillary carcinoma cells were positive for cytokeratins 7 and 20, carcinoembryonic antigen and CA125. Additionally, myofibroblasts were distributed in a chicken-wire pattern in the stroma of micropapillary carcinoma. Subsequently, the patient died of carcinoma 1 year after the onset of symptoms. Our results support the previous hypothesis that bladder micropapillary carcinoma runs an aggressive clinical course and suggest that micropapillary carcinoma may show the glandular differentiation of urothelial carcinoma and show the stromal reaction by myofibroblasts resembling that of carcinoma in other anatomic sites. |
| Databáze: | OpenAIRE |
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