Abstract 19504: Factors Predicting Sinus Rhythm in Patients Cardioverted in the X-VERT Study
| Autor: | Michael D Ezekowitz, Riccardo Cappato, Allan Klein, Isabelle L Ming, Melanie Hemmrich, Martin van Eickels, Stefan H Hohnloser |
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| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Circulation. 130 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circ.130.suppl_2.19504 |
| Popis: | Introduction: The X-VERT trial is the first large, prospective study of a novel oral anticoagulant in patients undergoing elective cardioversion. Patients were randomized to rivaroxaban (20mg or 15mg once daily if the CrCl was between 30 and 49 ml/min) or Vitamin K antagonist (VKA) at a ratio of 2:1. Patients were assigned to an early or delayed cardioversion strategy per the local investigator’s judgment. Aim: To determine factors predictive of sustained sinus rhythm at the end of treatment (i.e. 6 weeks) after cardioversion. Methods: Patients with non-valvular AF of >48 h or unknown duration were randomized. Univariate and multivariate analysis of logistic regressions were performed to detect potential predictors of clinically relevant variables. Results: A total of 1504 randomized patients were scheduled for either early (872 patients, 58%) or delayed (632 patients, 42%) cardioversion. 1398/1504 (93%) patients underwent cardioversion (electrical or pharmacological) or experienced spontaneous cardioversion during the treatment period. The time intervals from randomization to their first cardioversion (electrical n=1,253, pharmacological n=29 or spontaneous n=116) were 2.7 ± 2.8 days versus 27.9 ± 10.1 days for early versus delayed cardioversion. The acute success of their first cardioversion (electrical or pharmacological) was seen in 1107/1282 (86.3%) patients. At the end of treatment visit, 794/1504 (52.8%) patients were in sinus rhythm. In the multivariate analysis early cardioversion was a strong predictor of sustained sinus rhythm (p Conclusions: In X-VERT, early cardioversion was predictive of sustained sinus rhythm. Shorter duration AF correlated with sinus rhythm. |
| Databáze: | OpenAIRE |
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