| Autor: |
Katherine E. Campbell, Jun Song, Hiroshi Saito, Marlene E. Starr, Jing Li, B. Mark Evers |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Journal of the American College of Surgeons. 217:S18 |
| ISSN: |
1072-7515 |
| DOI: |
10.1016/j.jamcollsurg.2013.07.024 |
| Popis: |
RESULTS: We found that gdT cells home to the pancreas during acute and chronic pancreatitis in both mice and humans coincident with an elevation in intra-pancreatic NKG2D ligands. In mice, adoptive transfer of gdT cells exacerbated pancreatitis whereas depletion using monoclonal antibodies as well as use of Tcrd-/mice (which lack gdT cells) afforded protection. Intrapancreatic gdT cells exhibited a distinct phenotype compared with gdT cells in other compartments, including high expression of adhesion and co-stimulatory molecules, as well as pattern recognition receptors. Compared to gdT cells in other compartments, intra-pancreatic gdT cells produced high levels of TNF-alpha and IL-17A. Co-culture studies revealed that the ability of gdT cells to crosstalk and activate other pro-inflammatory cells, such as macrophages and dendritic cells exacerbated pancreatic inflammation. Finally, correlative analyses of human specimens yielded similar findings. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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