Feasibility Study Comparing Oral Paracetamol and Oral Non-Steroidal Anti-Inflammatory Drugs for Treating Pain after Musculoskeletal Injury: a Randomised, Double Blind, Controlled Trial

Autor: P. K. W. Lam, William W.K. Woo, S. Y. Man, Timothy H. Rainer
Rok vydání: 2004
Předmět:
Zdroj: Hong Kong Journal of Emergency Medicine. 11:78-84
ISSN: 2309-5407
1024-9079
DOI: 10.1177/102490790401100203
Popis: Objectives To investigate the efficacy and safety of oral paracetamol compared with oral non-steroidal anti-inflammatory drugs (NSAIDs) or combination therapy in relieving pain after limb injury in an emergency department. Design Double blind, randomised, controlled study. Setting Emergency department of a university hospital in the New Territories of Hong Kong. Subjects 50 adult patients with painful isolated limb injuries. Main outcome measures Primary outcome measures were pain relief at rest and with limb movement, and adverse events. Results There was no statistical difference in the mean reduction in pain score between oral paracetamol and oral NSAIDs in the first two hours of treatment or over three days. Patients' pain reduced significantly over three days but it was unclear whether this was due to natural healing rather than analgesic medication. There was no significant difference in pain relief between paracetamol and NSAIDs over three days treatment. All combinations appeared to be safe with no major adverse effects reported in the study. Conclusion Oral paracetamol may be as effective and as safe as moderate dose of NSAIDs in the management of musculoskeletal pain. A larger study is required to confirm this hypothesis.
Databáze: OpenAIRE
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