Effect of TiF4 varnish on microbiological changes and caries prevention: in situ and in vivo models
| Autor: | Luciana Salles Branco-de-Almeida, Camila Nassur, Lucianne Cople Maia, Carolina Bezerra Cavalcanti Nóbrega, Aline de Almeida Neves, Kátia Regina Netto dos Santos, Pedro Luiz Rosalen, Ana Maria Gondim Valença, Adílis Kalina Alexandria, Alexandre R. Vieira |
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| Rok vydání: | 2018 |
| Předmět: |
biology
Enamel paint business.industry Varnish Fluoride varnish Dentistry 030206 dentistry biology.organism_classification Streptococcus sobrinus stomatognathic diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry In vivo 030220 oncology & carcinogenesis visual_art Toxicity visual_art.visual_art_medium Titanium tetrafluoride business General Dentistry Fluoride |
| Zdroj: | Clinical Oral Investigations. 23:2583-2591 |
| ISSN: | 1436-3771 1432-6981 |
| Popis: | The aim of this study was to evaluate microbiological changes, oral soft tissue toxicity, and caries-preventive effect of an experimental titanium tetrafluoride (TiF4) varnish compared with a commercially available fluoride varnish (NaF), using in situ and in vivo models. The treatment groups were the following: TiF4 varnish (experimental varnish), Duraphat® (fluoride positive control), placebo varnish (no fluoride), and no treatment (negative control). The varnishes were applied once over the enamel surface using a microbrush. For the in vivo study, 48 Wistar rats were infected with Streptococcus sobrinus 6715, received a treatment, and were submitted to a cariogenic challenge. After 4 weeks, S. sobrinus, oral soft tissue toxicity, presence, and severity of caries were evaluated. For the in situ study, 12 volunteers took part in this randomized crossover, double-blind study performed in four phases of 14 days each. They used intraoral appliances containing four enamel specimens that received the varnish according treatment group. After 24 h, the varnish was removed and plaque accumulation was allowed. A 20% sucrose solution was dripped over the enamel blocks (10×/day for 5 min each). Total streptococci, S. mutans, Lactobacillus, Candida spp. counts, and presence of white spot lesions were evaluated. Lesion depth was also quantified by micro-CT. For the in vivo study, the fluoride (F-varnishes) showed a statistically significant reduction in the percentage of S. sobrinus compared to the negative control (p 0.05). However, the specimens treated with TiF4 exhibited lower percentage of white spot lesions and the lesion depth was significantly reduced by F-varnishes (p |
| Databáze: | OpenAIRE |
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