Genetic changes during immortalization of human cells

Autor:	Eileen M. Rogan, Kenneth Maclean, Jane R. Noble, Tracy M. Bryan, Roger R. Reddel, Andy C.-M. Chang, Noel J. Whitaker
Rok vydání:	1995
Předmět:	Mutation Telomerase Radiation Radiological and Ultrasound Technology Biology medicine.disease_cause Telomere Oncology Cell culture Stanniocalcin Gene expression medicine Cancer research Radiology Nuclear Medicine and imaging Allele Gene
Zdroj:	Radiation Oncology Investigations. 3:299-306
ISSN:	1520-6823 1065-7541
DOI:	10.1002/roi.2970030610
Popis:	Spontaneous immortalization of fibroblasts containing an inherited mutation of one p53 allele was associated with loss of the wild-type p53 allele and loss of p16INK4 gene expression, but this combination of genetic events was insufficient for immortalization. Loss of p16INK4 expression appears to be an alternative to loss of functional retinoblastoma gene product. In all cell lines studied, immortalization was associated either with stabilization of telomere length in the presence of telomerase activity or with the acquisition of long and heterogeneous telomeres in the absence of detectable telomerase. The role of other genes, such as human stanniocalcin, in the immortalization process is under investigation. © 1995 Wiley-Liss, Inc.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5eb705126d32dcd96577ef17c53cbefb https://doi.org/10.1002/roi.2970030610 Zobrazit plný text záznamu Plný text