Association of OPRK1 rs963549 and rs997917 polymorphisms with opioid use disorder and the related phenotypes

Autor:	Selin Özkan-Kotiloğlu, Dilek Kaya-Akyüzlü, Şafak Yalçın-Şahiner, Nagihan Ayaz
Rok vydání:	2023
Předmět:	Pharmacology Genetics Molecular Medicine
Zdroj:	Pharmacogenomics.
ISSN:	1744-8042 1462-2416
DOI:	10.2217/pgs-2023-0037
Popis:	Aim: To evaluate the association between OPRK1 rs963549 and rs997917 and opioid use disorder (OUD) and related phenotypes. Methods: A sample of 208 individuals with (n = 100) and without (n = 108) OUD were enrolled. OPRK1 rs963549 and rs997917 were analyzed by PCR–RFLP. Craving, opioid withdrawal and the intensity of depressive and anxiety symptoms were measured by the appropriate scales. Results: OPRK1 rs963549 variation showed a trend of association with decreased opioid withdrawal. No significant associations were found between OPRK1 rs963549 and rs997917 polymorphisms and craving, depression or anxiety symptoms. Neither single OPRK1 SNPs nor OPRK1 haplotypes were associated with OUD. Conclusion: Our results could be useful for treatment failures of individuals who experience greater opioid withdrawal due to their OPRK1 rs963549 genotypes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5e9724a148f95945a6262df00b85655d https://doi.org/10.2217/pgs-2023-0037 Zobrazit plný text záznamu