Novel Inflammatory Marker in Dialysis Patients: YKL-40
| Autor: | Ramazan Erdem Er, Ulver Derici, Merve Yasemin Tekbudak, Kadriye Altok, Kürşad Öneç, Hatice Pasaoglu, Gülay Ulusal Okyay, Ozge Tugce Pasaoglu, Salih Inal, Yasemin Erten |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Creatinine education.field_of_study biology business.industry medicine.medical_treatment Population Serum albumin Hematology Gastroenterology Surgery Peritoneal dialysis Proinflammatory cytokine chemistry.chemical_compound chemistry Nephrology Internal medicine biology.protein Medicine Population study Hemodialysis business education Dialysis |
| Zdroj: | Therapeutic Apheresis and Dialysis. 17:193-201 |
| ISSN: | 1744-9979 |
| DOI: | 10.1111/j.1744-9987.2012.01141.x |
| Popis: | YKL-40 has been introduced as a marker of inflammation in different clinical situations. The association between YKL-40 and inflammation in chronic renal failure patients has not been researched currently. The objectives of this study were to establish serum YKL-40 concentrations in dialysis patients with chronic renal failure compared to healthy subjects and to explore its relationships with a proinflammatory cytokine, interleukine-6 (IL-6) and an acute phase mediator, high sensitivity C-reactive protein (hs-CRP). The study population included hemodialysis patients (N = 43; mean age of 40.9 ± 14.5), peritoneal dialysis patients (N = 38; mean age of 45.8 ± 13.7) and healthy subjects (N = 37; mean age of 45.5 ± 10.6). Serum concentrations of YKL-40, IL-6, hs-CRP and routine laboratory measures were evaluated. Compared to the healthy subjects, hemodialysis and peritoneal dialysis patients had higher concentrations of YKL-40, IL-6, hs-CRP, as well as lower concentrations of hemoglobin, serum albumin and high density lipoprotein-cholesterol (P < 0.001). YKL-40 concentrations were positively correlated with serum creatinine (P < 0.001, r = 0.495), IL-6 (P < 0.001, r = 0.306), hs-CRP (P = 0.001, r = 0.306) levels and inversely correlated with hemoglobin (P = 0.002, r = -0.285), serum albumin (P < 0.001, r = -0.355) and high density lipoprotein-cholesterol (P = 0.001, r = -0.306). In multivariate regression analysis YKL-40 was associated with creatinine, serum albumin and hs-CRP concentrations after adjustments with covariates. Dialysis patients with chronic renal failure have elevated serum YKL-40 concentrations. Associations with standard inflammatory parameters suggest that YKL-40 might be a novel inflammatory marker in this population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text