Polimorfismo +49 A/G del gen del antígeno 4 del linfocito T citotóxico (CTLA-4) en la diabetes tipo 1: Asociación con el perfil de anticuerpos y citoquinas

Autor:	Ethel Codner D, Ivan Balic N, Elena Carrasco P, Francisco Pérez B, Bárbara Angel B
Rok vydání:	2009
Předmět:	Type 1 diabetes Cytokine Cytotoxic T-Lymphocyte-Associated Antigen 4 medicine.medical_treatment Immunology medicine Hla genes General Medicine Biology medicine.disease Dominance (genetics)
Zdroj:	Revista médica de Chile. 137
ISSN:	0034-9887
DOI:	10.4067/s0034-98872009000300001
Popis:	Cytotoxic T lymphocyte associated antigen 4 (CTLA-4)has been one of the non HLA genes more commonly studied in type 1 diabetes mellitus (TID). CTLA-4 isa co-stimulation protein that has a key role in the negative regulation of T cells and is related with afunctional cytokine imbalance, generating a T helper (Th) 1 over Th2 dominance.
Databáze:	OpenAIRE
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