Tannic Acid Inhibits Non-small Cell Lung Cancer (NSCLC) Stemness by Inducing G0/G1 Cell Cycle Arrest and Intrinsic Apoptosis
| Autor: | Kyoung-Jin Jang, Dong Young Kang, Eun Seong Jo, Doh Hoon Kim, Nipin Sp, Alexis Rugamba, Young Mok Yang, Ji-Seung Yoo |
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| Rok vydání: | 2020 |
| Předmět: |
A549 cell
Cancer Research Cell cycle checkpoint Intrinsic apoptosis non-small cell lung cancer (NSCLC) macromolecular substances General Medicine respiratory system medicine.disease respiratory tract diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oncology chemistry Gentamicin protection assay Apoptosis 030220 oncology & carcinogenesis Tannic acid medicine Cancer research Lung cancer |
| Zdroj: | Anticancer Research. 40:3209-3220 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.14302 |
| Popis: | Background/aim Non-small cell lung cancer (NSCLC) is one among the most common cancers worldwide. Recently, dietary phytochemicals have been reported as an attractive approach to improve the symptoms of NSCLC patients. Tannic acid is a natural polyphenol, which is known to have anticancer effects on in vitro models of breast, gingival and colon cancer. However, the molecular mechanisms associated with the actions of tannic acid on A549 human lung cancer cells have not been elucidated. Materials and methods In this study, we analyzed the effect of tannic acid on A549 cells and their underlying mechanisms using western blotting, flow cytometry, invasion assay and tumorsphere formation assay. Results Tannic acid treatment suppressed the viability of A549 cells through cell cycle arrest and induction of the intrinsic pathways of apoptosis. In addition, the various malignant phenotypes of A549 cells including invasion, migration, and stemness were inhibited by tannic acid treatment. Conclusion Tannic acid could be used as an effective inhibitor of lung cancer progression. |
| Databáze: | OpenAIRE |
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