Intermittent Preventive Treatment during Pregnancy with Sulphadoxine-Pyrimethamine May Promote Plasmodium falciparum Gametocytogenesis
| Autor: | S.B. Adeoye, S T Balogun, Fatai A. Fehintola |
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| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Medical Principles and Practice. 21:63-67 |
| ISSN: | 1423-0151 1011-7571 |
| Popis: | Objectives: To determine the incidence of gametocytes and the propensity of sulphadoxine-pyrimethamine to promote gametocytogenesis when used as intermittent preventive treatment in pregnancy. Subjects and Methods: This observational non-interventional study assessed the influence of intermittent preventive treatment with sulphadoxine-pyrimethamine on Plasmodium falciparum gametocytaemia among Nigerian pregnant women. A total of 306 pregnant women were enrolled in the study. Results: The 306 pregnant women had 711 events, of which 31 pure gametocytaemic episodes were documented and 27 were recorded among the intermittent preventive treatment users. Only 4 episodes of pure gametocytaemia were recorded in pregnant women who did not receive any dose of sulphadoxine-pyrimethamine (27/129 vs. 4/276, χ2 = 15.9, p = 0.00006). Conclusion: Our findings show that intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine may predispose to gametocyte carriage in pregnant women resident in the hyperendemic malaria region of southwest Nigeria. We therefore suggest that the use of insecticide-treated nets be encouraged among pregnant women resident in malaria-endemic sub-Saharan Africa in order to reduce malaria transmission. |
| Databáze: | OpenAIRE |
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