Biomimetic dense lamellar scaffold based on a colloidal complex of the polyaniline (PANi) and biopolymers for electroactive and physiomechanical stimulation of the myocardial
| Autor: | Venancio Alves Amaral, Norberto Aranha, Thais Francine Ribeiro Alves, Patrícia Severino, Denise Grotto, Danilo Araujo Almeida, Lindemberg da Mota Silveira Filho, Alexandro Barbosa de Souza, Marco Vinícius Chaud, José Martins de Oliveira Junior, Renata de Lima, Juliana Ferreira de Souza, Cecilia Torqueti de Barros |
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| Rok vydání: | 2019 |
| Předmět: |
Scaffold
Materials science Fibroin 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Colloid Colloid and Surface Chemistry Isoelectric point chemistry Chemical engineering Polyaniline Zeta potential Moiety Lamellar structure 0210 nano-technology |
| Zdroj: | Colloids and Surfaces A: Physicochemical and Engineering Aspects. 579:123650 |
| ISSN: | 0927-7757 |
| DOI: | 10.1016/j.colsurfa.2019.123650 |
| Popis: | A novel biodegradable conductive scaffold containing water-soluble polyaniline (PANi) was manufacture. The conductive dense lamellar scaffolds were obtained by a mixture of collagen, fibroin solution, hyaluronic acid, and water-soluble polyaniline, using plastic compression method. Scaffolds held open and interconnected pores having a pore size ranging from several 100 to 150 μm. PANi-scaffolds had compression modulus and strength of 1.77 ± 0.11 MPa. The isoelectric point of the scaffold was observed by surface zeta potential in pH 7.7. The conductivity of the scaffold was measured as 2.10–6 S.cm−1 for dry PANi-scaffold and 6.10-4 S. cm−1 for hydrated. The PANi-scaffold has physiomechanical, and physico-chemical properties supported the viability and proliferation of cardiomyocytes. Our results highlight the potential of incorporation of PANi as an electroactive moiety for induction of cardiomyocyte proliferation and repair of damaged heart tissue. |
| Databáze: | OpenAIRE |
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