Clinical Application and Evaluation of Population Pharmacokinetic Parameters in Phenytoin Dosage Adjustment

Autor:	Yukawa Eiji, Higuchi Shun, Nonaka Toshiharu, Inoue Kazuhide, Aoyama Toshinobu, Kuroda Takeshi
Rok vydání:	1993
Předmět:	Phenytoin education.field_of_study Pharmacokinetics Mean squared prediction error Statistics Bayesian probability Population medicine Dosage adjustment Prediction bias education Mathematics medicine.drug
Zdroj:	Japanese Journal of Hospital Pharmacy. 19:1-7
ISSN:	2185-9477 0389-9098
Popis:	We investigated the influence and the usefulness of the population pharmacokinetic parameters (PPP) reported by Sheiner et al.[I], Grasera et al.[II], Miller et al.[III], IIIrd committee [IV] and Yukawa et al.[V], on the performance of the Bayesian feedback method in predicting the phenytoin (PHT) dosage.The predictabilites of the Bayesian feedback method using the data of 96 epileptic patients were evaluated. The mean prediction error and mean absolute predection error were applied for measures of prediction bias and precision. The precision of the initial estimates based on the PPP set [V] and [II] were superior to those baced on other parameters. Using the Bayesian feedback method the prediction values improved from the initial estimates were obtained regardless of the PPP sets used. The Bayesian feedback method seemed to give a prediction relatively insensitive to the population parameters used. We also found no inter-institutional differences in predicting the PHT dosage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5e80365330ddc6b76347b0663b406435 https://doi.org/10.5649/jjphcs1975.19.1 Zobrazit plný text záznamu