Immediate effects of UV radiation on the skin: modification by an antioxidant complex containing carotenoids
| Autor: | M Béjot, J P Césarini, H Adhoute, J M Maurette, Laurence Michel |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Antioxidant
Erythema Chemistry Thiobarbituric acid medicine.medical_treatment Immunology Dermatology General Medicine Pharmacology medicine.disease_cause medicine.disease Skin Aging Melanin chemistry.chemical_compound Biochemistry Photoprotection medicine Immunology and Allergy Radiology Nuclear Medicine and imaging medicine.symptom Sunburn Oxidative stress |
| Zdroj: | Photodermatology, Photoimmunology & Photomedicine. 19:182-189 |
| ISSN: | 0905-4383 |
| DOI: | 10.1034/j.1600-0781.2003.00044.x |
| Popis: | Background/Aims: The ultraviolet (UV) portion of sunlight is involved in the induction and development of skin cancers against which a limited photoprotection may be provided by reduced time of exposure, clothing, and sunscreen applications. The concept of an effective, safe, systemic photoprotection will circumvent many of the shortcomings. The UV-induced oxidative stress is a cause of DNA damage and a few publications have shown, in humans, minimal benefits, if any, of the oral intake of antioxidant complex, contrasting with the large literature showing beneficial effects in vitro or in animal models. Methods: We investigated, in 25 healthy individuals, the capacity of an antioxidant complex (AOC) – vitamins (lycopene, β-carotene, α-tocopherol), selenium – to reduce UV-induced damages. The AOC was administered orally, daily during 7 weeks. Before and after irradiations, before and after the intake of the product, six parameters were studied: skin color by chromametry, minimal erythemal dose and, on skin biopsies, sunburn cells (SBCs), p53 detected by immunohistochemistry, pigmentation index, and levels of lipoperoxides (thiobarbituric acid reaction). Results: After the oral intake of AOC, we observed an elevation of the actinic erythema threshold (+20%, P=0.01) and a general reduction of the UV-induced erythemas, a reduction of the UV-induced p53 expression (P |
| Databáze: | OpenAIRE |
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