| Autor: |
Anya J. O’Neal, Nisha Singh, Iain S. Forrest, Agustin Rolandelli, Xiaowei Wang, Dana K. Shaw, Brianna D. Young, Sukanya Narasimhan, Shraboni Dutta, Greg A. Snyder, Liron Marnin, L. Rainer Butler, Sourabh Samaddar, M. Tays Mendes, Francy E. Cabrera Paz, Luisa M. Valencia, Eric J. Sundberg, Erol Fikrig, Utpal Pal, David J. Weber, Ron Do, Joao H.F. Pedra |
| Rok vydání: |
2022 |
| Předmět: |
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| DOI: |
10.1101/2022.02.09.479763 |
| Popis: |
Pattern recognition receptors sense pathogens in arthropods and mammals through distinct immune processes. Whether these molecules share a similar function and recognize the same microbe in evolutionarily distant species remain ill-defined. Here, we establish that the CD36 superfamily is required forBorrelia burgdorferiresistance in both the arthropod vector and humans. Using the blacklegged tickIxodes scapularisand an electronic health record-linked biobank, we demonstrate that CD36 members elicit immunity to the Lyme disease spirochete. In ticks, the CD36-like protein Croquemort recognizes lipids and initiates the immune deficiency and jun N-terminal kinase pathways againstB. burgdorferi. In humans, exome sequencing and clinical information reveal that individuals withCD36loss-of-function variants have increased prevalence of Lyme disease. Altogether, we discovered a conserved mechanism of anti-bacterial immunity.One Sentence SummaryLipid receptors belonging to the CD36 superfamily exhibit a shared immune function in both ticks and humans. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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