Synthesis of Hybrid Peptidomimetics and Neoglycoconjugates Employing Click Protocol: Dual Utility of Poc-Group for Inserting Carbamate-Triazole Units into Peptide Backbone
| Autor: | Hosahalli P. Hemantha, Vommina V. Sureshbabu, Ravi S. Lamani |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
chemistry.chemical_classification
Carbamate 1 2 3-Triazole Peptidomimetic medicine.medical_treatment Triazole Bioengineering Peptide Biochemistry Combinatorial chemistry Cycloaddition Analytical Chemistry Amino acid chemistry.chemical_compound chemistry Drug Discovery medicine Click chemistry Molecular Medicine |
| Zdroj: | International Journal of Peptide Research and Therapeutics. 16:267-275 |
| ISSN: | 1573-3904 1573-3149 |
| DOI: | 10.1007/s10989-010-9228-6 |
| Popis: | Synthesis of new types of peptidomimetics and glycosylated amino acids possessing 1,2,3-triazole and carbamate moieties is described. Poc-protected amino acid esters/1-amino sugars were subjected to Cu(I) catalyzed [2+3]cycloaddition with desired azides under click protocol to obtain novel peptide and carbohydrate mimetics. The reaction is rapid, efficient and all the products are isolated in good yield and excellent purity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink