Three new labdane diterpenes from Loxocalyx urticifolius
| Autor: | Li-Sheng Ding, Yan Zhou, Da-Le Guo, Yu-Cheng Gu, Min Zhao, Lei Chen, Lv-Yi Yuan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
biology
010405 organic chemistry Stereochemistry Absolute configuration Plant Science 010403 inorganic & nuclear chemistry biology.organism_classification Selective cytotoxicity 01 natural sciences Biochemistry 0104 chemical sciences Labdane chemistry.chemical_compound chemistry Loxocalyx urticifolius Ic50 values Lamiaceae Spectral analysis Agronomy and Crop Science Human cancer Biotechnology |
| Zdroj: | Phytochemistry Letters. 19:55-59 |
| ISSN: | 1874-3900 |
| Popis: | Three new labdane diterpenes, namely loxocalyxin D (1), loxocalyxin E (2) and 13-epiloxocalyxin E (3), were isolated from the whole plants of Loxocalyx urticifolius Hemsl. Their structures were elucidated by extensive spectral analysis and chemical methods. The absolute configuration of loxocalyxin D (1) was confirmed by X-ray crystallographic analysis. The cytotoxic activities of the isolated labdane diterpenes were evaluated against the four human cancer cell lines A549, HepG2, HL-60 and MCF-7. 13-epiloxocalyxin E (3) exhibited selective cytotoxicity against A549 and MCF-7 with the IC50 values of 22.4 and 47.3 μM, respectively. |
| Databáze: | OpenAIRE |
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