Morphoanatomy of striated myofibers in streptozotocin-induced diabetic wistar rats: assuaging effect of combined doses of Vernonia amygdalina and Azadirachta indica
| Autor: | T. Danboyi, O.M. Avidime, A.A. Odetola, O.V. Adeteye, K.A. Mohammed, O.E. Yama, T.O. Kusemiju |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
biology business.industry Vernonia amygdalina Glutathione peroxidase Glutathione Pharmacology Azadirachta biology.organism_classification medicine.disease Streptozotocin Metformin chemistry.chemical_compound chemistry Diabetes mellitus medicine biology.protein Pharmacology (medical) business medicine.drug Peroxidase |
| Zdroj: | Research Journal of Health Sciences. 8:92-101 |
| ISSN: | 2467-8252 2360-7793 |
| DOI: | 10.4314/rejhs.v8i2.5 |
| Popis: | Objective: This study aimed to evaluate the effects of Azadirachta indica and Vernonia amygdalina extracts on the morphoanatomy of striated myofibrils in diabetic rat models. Methodology: Thirty Wistar rats randomly assigned into 5 groups of 6 rats/group were used. Group A received distilled water only, B (herbal) received A. indica (500 mg/kg/day) and V. amygdalina (400 mg/kg/day) simultaneously, C were diabetic rats, D were diabetic rats treated with herbal extracts combined and E, diabetic rats treated with metformin. Diabetes was induced with streptozotocin (70 mg/kg). Muscles glutathione peroxidase (GPx) and blood glucose levels were determined. The rats were sacrificed at the end of 60days treatment. The quadriceps femoris muscle harvested for histology. Results: Diabetic herbal treated rats became euglycemic by the end of 8 weeks. GPx activity was significantly (p |
| Databáze: | OpenAIRE |
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