ChemInform Abstract: Synthesis and Action on the Central Nervous System of Some N2- Substituted Cinnoline Derivatives

Autor:	W. Pakulska, A. Szadowska, Stańczak A, Kwapiszewski W
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Ethyl bromoacetate medicine.anatomical_structure chemistry Stereochemistry Central nervous system medicine chemistry.chemical_element Organic chemistry General Medicine Zinc Alkylation Cinnoline
Zdroj:	ChemInform. 25
ISSN:	0931-7597
DOI:	10.1002/chin.199443181
Popis:	Alkylation of 4-hydroxycinnolines using ethyl bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.
Databáze:	OpenAIRE
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