HPLC-based quality control of cytarabine preparations

Autor:	D. V. Moiseev, L. P. Gubina, P. T. Petrov, T. V. Trukhacheva, A. I. Zhebentyaev, S. I. Marchenko
Rok vydání:	2006
Předmět:	Pharmacology Aqueous solution Chromatography Chemistry Deamination Cytidine High-performance liquid chromatography Uridine chemistry.chemical_compound Hydrolysis Drug Discovery Cytarabine medicine Uracil Arabinoside medicine.drug
Zdroj:	Pharmaceutical Chemistry Journal. 40:678-682
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-006-0218-0
Popis:	An HPLC-based method for determining cytarabine (1-β-D-arabinofuranosylcytosine, Ara-C) and uracil arabinoside (Ara-U, a product of the hydrolytic deamination of Ara-C), as well other related compounds (cytidine, cyclocytidine, uridine), in aqueous solutions has been developed. The proposed method is characterized by good reproducibility and is capable of quantitatively determining all compounds simultaneously present in solution.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5e4fd57de2324e08e9c4ae7222da7e0c https://doi.org/10.1007/s11094-006-0218-0 Zobrazit plný text záznamu Plný text ve formátu PDF