Tumor growth suppression after xenografting of human colorectal carcinoma cells

Autor:	Mikhail Liskovykh, Alexey Tomilin, A. P. Davydov-Sinitsyn, Rashida Orlova, S. A. Koshkin, Olga Bajenova, S. V. Ponomartsev, I. V. Rykov, E. N. Tolkunova
Rok vydání:	2015
Předmět:	education.field_of_study Colorectal cancer Population Cell Cell Biology Biology medicine.disease medicine.anatomical_structure Cancer stem cell In vivo Cell culture Cancer cell Immunology medicine Cancer research education Clonogenic assay
Zdroj:	Cell and Tissue Biology. 9:318-325
ISSN:	1990-5203 1990-519X
Popis:	Previously, we have described the establishment of a subpopulation of cancer stem cells from the human colorectal carcinoma cell line MIP101. These cells exhibit enhanced clonogenic and tumorigenic capacities. Depletion of the stem compartment in the cancer cell population blocks its tumorigenicity. The present work is dedicated to a comparison of the tumorigenic potential of cell populations with an enriched or depleted stem compartment. We showed that tumor growth after xenografting of an enriched stem cell population can be suppressed by intramuscular injections of ganciclovir. Thus, we suggest an approach to isolating a cell population with high Oct4 promoter expression in the MIP101 colorectal carcinoma line and eliminating these cells from the population in vitro as well as in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5e3e8a2a6a28f366f1a5d404465ef45a https://doi.org/10.1134/s1990519x15040045 Zobrazit plný text záznamu Full text from SpringerLink