Expression of M-CSF, TNF-β, IFN-γ, and IL-10 in Rats with Liver Cirrhosis and Hypersplenism and its Significance
| Autor: | Yunfu Lv, Xinqiu Li, Qingqing Li, Jie Deng, Bookyong Yu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pathology Cirrhosis business.industry Phagocytosis Mrna expression medicine.medical_treatment CCL4 Spleen medicine.disease Peripheral 03 medical and health sciences Interleukin 10 030104 developmental biology Endocrinology medicine.anatomical_structure Cytokine Internal medicine medicine business |
| Zdroj: | Journal of Hypertension: Open Access. |
| ISSN: | 2167-1095 |
| DOI: | 10.4172/2167-1095.1000234 |
| Popis: | Objective: This study aimed to examine the expression of M-CSF, TNF-β, IFN-γ, and IL-10 in rats with liver cirrhosis and hypersplenism, and to investigate its significance. Methods: Seventy-two healthy male SD rats were randomly divided into a model group (n=60) and a control group (n=12). The rats in the model group were first gavaged with a 40% CCL4/peanut oil solution to develop cirrhosis and hypersplenism. The expression rates and intensities of the pro-inflammatory cytokines M-CSF, TNF-β, and IFN-γ, and the anti-inflammatory cytokine IL-10 in the spleen were measured and compared with the control group. The pro-inflammatory/anti-inflammatory cytokine ratio and its role were analyzed. Results: The positive expression rates of M-CSF, TNF-β, IFN-γ, and IL-10 in the model group (cirrhosis and hypersplenism) were 61.76%, 79.41%, 64.70%, and 88.24%, respectively, which were significantly different (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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