Immunologic Studies of Anthrax
| Autor: | Frederick Klein, Bertram W. Haines, Bill G. Mahlandt, Ralph E. Lincoln |
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| Rok vydání: | 1963 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 91:431-437 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.91.4.431 |
| Popis: | Summary The effects of anthrax immunization on the serum antibody titer and the immunity index were compared for guinea pigs and rats immunized by two protocols. An association between the two measures could not be detected in either species of animals immunized at any one level; however, when data on animals immunized at several levels were combined, a weak but significant association became apparent. The results of the agar diffusion test were more variable than those of the immunity index, and at relatively low or intermediate levels of protection the agar diffusion test produced a much larger portion of false negatives. This weakness did not carry through to animals protected to a high level of resistance, although at nearly all levels of protection the immunity index was more precise than the serologic test. From these observations on animals we conclude that with human beings serum titers of less than 1:32 may be unreliable as an index of protection against anthrax. Titers of 1:64 or greater probably indicate some significant degree of resistance although the same titer observed for two individuals may indicate different degrees of resistance to the disease. |
| Databáze: | OpenAIRE |
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