IDDF2018-ABS-0203 Modulation of intestinal dysbiosis in patients with constipation-predominant irritable bowel syndrome using lactobacillus-containing cultured milk drink
| Autor: | Norshafila Diana Mohd Rathi, Norhayati Md Jaafar, Rafiz Abdul Rani, Norfilza Mohd Mokhtar, Seow-Neng Chan, Liyana Zaharuddin |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Cultured milk Lactobacillus paracasei biology business.industry food and beverages Gut flora medicine.disease biology.organism_classification Gastroenterology Pathogenesis Lactobacillus acidophilus Internal medicine Lactobacillus medicine business Dysbiosis Irritable bowel syndrome |
| Zdroj: | Clinical Gastroenterology. |
| DOI: | 10.1136/gutjnl-2018-iddfabstracts.152 |
| Popis: | Background Dysbiosis of gut microbiota is postulated to play a role in the pathogenesis of irritable bowel syndrome. A safe and affordable strategy to maintain gut microbiome homeostasis is by introducing cultured milk drink. This study aimed to investigate the effects of lactobacillus-containing cultured milk drink on clinical symptoms and circulating pro-inflammatory cytokines in subjects with constipation-predominant irritable bowel syndrome (IBS-C) as compared to controls. Methods Subjects fulfilling Rome III criteria for IBS-C were recruited. Each subject had to drink three bottles of 12=cultured milk drink daily for 30 days, each containing 109 cfu of live bacteria consists of Lactobacillus acidophilus and Lactobacillus paracasei with 4.06 g/10=of fructose, 4.14 g/10=glucose, 0.29 g/10=sucrose, Results About 77 IBS-C with 88 controls (mean age: 29.71±8.79 and 29.27±7.64 years old respectively) were recruited. At 30 days of post-consumption, majority (97.4%) of IBS-C had improvement in constipation-related symptoms, and faecal pH was significantly reduced from 6.13±0.57 to 5.94±0.37 (p Conclusions Daily consumption of cultured milk drinks for 30 days is beneficial to improve constipation-related symptoms, reduces faecal pH, ITT and pro-inflammatory cytokines among IBS-C patients. Consideration should be made to include cultured milk drink as an option in the treatment of IBS-C. |
| Databáze: | OpenAIRE |
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