A randomized prospective study of misoprostol and dinoproston for induction of labor
| Autor: | Patrick Belfrage, L. K. Gjessing, E. Smedvig, Torbjørn Moe Eggebø, Inger Økland |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pregnancy
medicine.medical_specialty Randomization Obstetrics business.industry medicine.medical_treatment Uterus Obstetrics and Gynecology Prostaglandin General Medicine medicine.disease law.invention chemistry.chemical_compound medicine.anatomical_structure Randomized controlled trial chemistry law Labor induction medicine business Cervix Misoprostol medicine.drug |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 79:1065-1068 |
| ISSN: | 0001-6349 |
| DOI: | 10.1034/j.1600-0412.2000.0790121065.x |
| Popis: | Background. Misoprostol, a prostaglandin E1 analog registered for the prevention of gastric ulcers in NSAID-drug users, has been reported to be more effective for labor induction than the standard prostaglandin, dinoproston after vaginal application. There have been some concerns about possible hyperstimulation of the uterine activity and about the safety for the fetus with this new drug.Methods. Two hundred and ten patients, 36 weeks pregnant or more, with an unfavorable cervix, single pregnancy, and intact membranes were randomized to receive misoprostol, 50 micrograms intravaginally every 6 hours, or dinoproston 0.5 mg intracervically every 12 hours for a maximum of 24 hours, for labor induction.Results. Time from induction to delivery was shorter in both primigravidae and multigravidae after the application of misoprostol than dinoproston and failed induction was more common after dinoproston than after misoprostol. There were no differences in the condition of the newborns in the two groups, accordin... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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