Interleukin-6 serum level and gene polymorphism in keloid patients
| Autor: | Kawthar Ibraheem Mohammed, Azza G. A. Farag, Azza M Abdu Allah, Mai Essam, Nermin Tayel, Magda M Hagag |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
medicine.medical_specialty biology business.industry 030302 biochemistry & molecular biology Interleukin General Medicine medicine.disease Gastroenterology 03 medical and health sciences Keloid Internal medicine Genotype medicine biology.protein Medical history Gene polymorphism Allele Family history skin and connective tissue diseases business Interleukin 6 |
| Zdroj: | Cellular and Molecular Biology. 65:43-48 |
| ISSN: | 1165-158X 0145-5680 |
| Popis: | The formation of keloid is associated with accumulation of extracellular matrix (ECM) formed mainly of collagen and fibronectin. Persistent deregulated IL-6 synthesis causes the development of various diseases. This study aim to investigate interleukin 6 (IL-6) serum level and gene polymorphism in a sample of Egyptian patients having keloid. This study was carried out on 90 subjects; 60 patients with keloid, and 30 age and sex matched apparently healthy control. All subjects underwent full history taking, clinical examinations, weight and length measuring to calculate BMI, dermatological examination, analysis of IL6-572 gene polymorphism using REFLP- PCR and IL-6 serum level using ELISA.IL-6 serum levels were significantly higher in keloid patients than control group (75.54±39.18) vs (19.17±6.06), (p |
| Databáze: | OpenAIRE |
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