Glutathione conjugated polyethylenimine on the surface of Fe3O4 magnetic nanoparticles as a theranostic agent for targeted and controlled curcumin delivery

Autor:	Maryam Dibaei, Mohammad Ali Akrami, Ismaeil Haririan, Firouzeh Nemati, Fatemeh Salehian, Fahimeh Salehi, Masoumeh Alipour, Mehdi Khoobi, Seyed Esmaeil Sadat Ebrahimi, Mohammad-Reza Rouini, Alireza Foroumadi, Mohammad Reza Ganjali, Saeed Safaei, Nader Riyahi Alam, Milad Ghorbani, Banafsheh Nikfar, Navid Aeineh
Rok vydání:	2018
Předmět:	0301 basic medicine Polyethylenimine Biomedical Engineering Biophysics Nanoparticle Bioengineering 02 engineering and technology Conjugated system 021001 nanoscience & nanotechnology Bioavailability Biomaterials 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry In vivo Curcumin Magnetic nanoparticles MTT assay 0210 nano-technology Nuclear chemistry
Zdroj:	Journal of Biomaterials Science, Polymer Edition. 29:1109-1125
ISSN:	1568-5624 0920-5063
DOI:	10.1080/09205063.2018.1427013
Popis:	Theranostics with the ability to simultaneous monitoring of treatment progress and controlled delivery of therapeutic agents has become as an emerging therapeutic paradigm in cancer therapy. In this study, we have developed a novel surface functionalized iron oxide nanoparticle using polyethyleneimine and glutathione for targeted curcumin (CUR) delivery and acceptable pH sensitive character. The developed magnetic nanoparticles (MNPs) were physicochemically characterized by FT-IR, XRD, FE-SEM and TEM. The MNPs was obtained in spherical shape with diameter of 50 nm. CUR was efficiently loaded into the MNPs and then in vitro release analyses were evaluated and showed that the prepared MNPs could release higher amount of CUR in acidic medium compared to neutral medium due to the pH sensitive property of the coated polymer. MTT assay confirmed the superior toxicity of CUR loaded MNPs compared to the control nanoparticles. Higher cellular uptake of the MNPs than negative control cells was demonstrated in SK-N-MC cell line. In vitro assessment of MRI properties showed that synthesized MNPs could be used as MRI imaging agent. Furthermore, according to hemolysis assay, the developed formulation exhibited suitable hemocompatibility. In vivo blood circulation analysis of the MNPs also exhibited enhanced serum bioavailability up to 2.5 fold for CUR loaded MNPs compared with free CUR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5e17bc4ade97650ae5eaecd0bf4cbbec https://doi.org/10.1080/09205063.2018.1427013 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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