Structure and activity studies of glycine receptor ligands, Part 3: structure and conformation of ethyl-N-[(5,5-diphenyl)-4-oxo-2-imidazolidyl]glycinate

Autor:	Witold Kwiatkowski, Waldemar Ksiazek, Jadwiga Handzlik, A. Mrozek, Janina Karolak-Wojciechowska, Katarzyna Kieć-Kononowicz
Rok vydání:	1998
Předmět:	Inorganic Chemistry Glycine binding Chemistry Stereochemistry Organic Chemistry MNDA Receptor Glycine receptor Tautomer Spectroscopy Analytical Chemistry
Zdroj:	Journal of Molecular Structure. 447:89-96
ISSN:	0022-2860
DOI:	10.1016/s0022-2860(98)00325-1
Popis:	As part of our investigation of compounds with potential affinity to the glycine binding site of MNDA receptors the structure of ethyl-N-[(5,5-diphenyl)-4-oxo-2-imidazolidyl]glycinate is reported: C 19 H 19 N 3 O 3 ; orthorombic; P2 1 2 1 2 1 ; a = 10.273(2), b = 10.309(2), c = 16.721(3) A ; V = 1770.8(6) A 3 ; Z = 4; λ( CuK α) = 1.54178 A ; μ = 0.71 mm −1 ; final R = 0.053 for 1002 observed reflections [ I > 4 σ ( I )]. Possible tautomers of this structure as well as possible conformations of the amino ester chain and their impact on the binding to the glycine binding site of MNDA receptors are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5e118b75fa1089d2b9e6f76dc0515a30 https://doi.org/10.1016/s0022-2860(98)00325-1 Zobrazit plný text záznamu Full Text from ScienceDirect