Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1
| Autor: | M K Racke, S Dhib-Jalbut, B Cannella, P S Albert, C S Raine, D E McFarlin |
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| Rok vydání: | 1991 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 146:3012-3017 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.146.9.3012 |
| Popis: | Experimental allergic encephalomyelitis (EAE) is an autoimmune disease characterized by inflammation and demyelination in the central nervous system. The effect of the immunosuppressive molecule transforming growth factor-beta, (TGF-beta 1) on chronic relapsing EAE produced by the transfer of myelin basic protein-specific T cell lines was studied. TGF-beta 1 markedly inhibited the activation and proliferation of myelin-basic protein-specific lymph node cells in vitro. This reduced the capacity of these cells to transfer EAE. In addition, administration of TGF-beta 1 in vivo consistently resulted in an improved clinical course, even when given during ongoing disease. Immunopathologic study demonstrated a marked reduction in central nervous system damage and expression of cell-surface lymphocyte function-associated Ag-1 and class II MHC molecules in TGF-beta 1-treated mice. These findings have identified TGF-beta 1 as a possible therapeutic agent for the human demyelinating disease multiple sclerosis. |
| Databáze: | OpenAIRE |
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