A Role for Skin γδ T Cells in Wound Repair

Autor:	Wendy L. Havran, Pia P. Yachi, Elaine Fuchs, Richard Boismenu, Nicole Chen, Karen Ugarte, Julie M. Jameson
Rok vydání:	2002
Předmět:	Multidisciplinary integumentary system T cell Dendritic cell T lymphocyte Biology Fibroblast growth factor Cell biology chemistry.chemical_compound medicine.anatomical_structure chemistry Immunology medicine Fibroblast Growth Factor 7 Keratinocyte growth factor Wound healing Keratinocyte
Zdroj:	Science. 296:747-749
ISSN:	1095-9203 0036-8075
Popis:	γδ T cell receptor–bearing dendritic epidermal T cells (DETCs) found in murine skin recognize antigen expressed by damaged or stressed keratinocytes. Activated DETCs produce keratinocyte growth factors (KGFs) and chemokines, raising the possibility that DETCs play a role in tissue repair. We performed wound healing studies and found defects in keratinocyte proliferation and tissue reepithelialization in the absence of wild-type DETCs. In vitro skin organ culture studies demonstrated that adding DETCs or recombinant KGF restored normal wound healing in γδ DETC-deficient skin. We propose that DETCs recognize antigen expressed by injured keratinocytes and produce factors that directly affect wound repair.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5dfdefc2ab65c8370f4c793ff1d036e6 https://doi.org/10.1126/science.1069639 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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