A dual functional fluorescent sensor for human serum albumin and chitosan
| Autor: | Xia Zhao, Yong Ju, Jianzuo Li, Yunqi Li, Jindan Wu, Ying Li, Jun Hu, Fengchao Cui, Yuan Lin |
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| Rok vydání: | 2017 |
| Předmět: |
Biocompatibility
Stereochemistry 02 engineering and technology 010402 general chemistry 01 natural sciences Chitosan Hydrophobic effect chemistry.chemical_compound Amphiphile Materials Chemistry medicine Electrical and Electronic Engineering Instrumentation Detection limit Metals and Alloys 021001 nanoscience & nanotechnology Condensed Matter Physics Human serum albumin Fluorescence Combinatorial chemistry 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Amine gas treating 0210 nano-technology medicine.drug |
| Zdroj: | Sensors and Actuators B: Chemical. 243:831-837 |
| ISSN: | 0925-4005 |
| Popis: | A dual functional AIE active amphiphilic molecule, sodium N,N’-bis[4-(3-sulfonatopropoxyl)] salicylidene (BSPS), was designed and synthesized. Due to its amphiphilic nature, BSPS could spontaneously enter into human serum albumin (HSA) cavities primarily promoted by hydrophobic forces, which restricted the rotation of N N single bond through rigidifying the conformation of BSPS, thus making BSPS display intense fluorescence with a broad working range (0–100 μg/mL) and a low detection limit (down to 6.11 μg/mL) for HSA. Meanwhile, BSPS could also aggregate on chitosan (CS) through electrostatic interactions between negative sulphate moieties in BSPS and positive amine groups in CS, consequently resulting in a sharp increase in fluorescence intensity, with a linear relationship from 0 to 10 μg/mL of CS and a detection limit of 0.58 μg/mL. Moreover, the outstanding biocompatibility of BSPS makes it an attractive multiple functional sensor candidate for detecting biomacromolecules in biosystem. |
| Databáze: | OpenAIRE |
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