Design, synthesis and binding affinities of novel non-peptide mimics of somatostatin/sandostatin®
| Autor: | Jean-Claude Depezay, Marie-Claude Burgevin, Evelyne James-Surcouf, Frédéric Herman, Michel Barreau, Marc Vuilhorgne, Yves Le Merrer, Serge Mignani, Guy Pantel, Lydie Poitout, Jean-Charles Blanchard, Dominique Damour, Adam Doble |
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| Rok vydání: | 1996 |
| Předmět: |
Chemistry
Somatostatin receptor Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Non peptide medicine.anatomical_structure Membrane Somatostatin Design synthesis Cerebral cortex Drug Discovery medicine Molecular Medicine Somatostatin receptor 2 Molecular Biology Binding affinities |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 6:1667-1672 |
| ISSN: | 0960-894X |
| Popis: | Based on molecular modelling studies of Sandostatin®, sugar-based derivatives I-VI were prepared as potential non-peptide mimics of somatostatin/Sandostatin®. These compounds displaced 3-[ 125 I]-Tyr 11 -SRIF-14 from the somatostatin receptor on membranes of rat cerebral cortex with IC 50 values between 10 and 15 μM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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