Antikörperkontrollierte zytostatische Therapie des malignen Thymoms bei begleitender Myasthenia gravis

Autor:	Schumm F, Brinkmann A, Fateh-Moghadam A
Rok vydání:	2008
Předmět:	Cisplatin Vincristine medicine.medical_specialty Malignant Thymoma Cyclophosphamide business.industry General Medicine medicine.disease Gastroenterology Myasthenia gravis Pyridostigmine Prednisone Internal medicine Concomitant medicine business medicine.drug
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 109:1244-1246
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1069357
Popis:	In a 46-year-old female patient with malignant thymoma and concomitant myasthenia gravis relapse with gravitational metastases occurred 6 1/2 years after the first operation. Metastases could be removed surgically only partially and were subsequently irradiated with 50 Gy. After 3 1/2 years renewed metastatic growth occurred. Until then the concomitant myasthenia had been stable during treatment with pyridostigmine and azathioprin and intermittent prednisone; acetylcholine receptor antibody titres had remained largely stable. Combined cytostatic treatment with vincristine, cyclophosphamide, prednisone and doxorubicin or cisplatin led to regression of metastases during the observation period of 1 1/2 years and at the same time to stabilisation of the myasthenia. Acetylcholine receptor antibody titres decreased and this was roughly paralleled by clinical improvement. Whereas there is no obvious correlation of antibodies against acetylcholine-receptor protein and tendency of tumour growth there is good agreement with the course of the accompanying myasthenia.
Databáze:	OpenAIRE
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