HLA-DQgene polymorphisms are associated with hepatocellular carcinoma and hepatitis B surface antigen in chronic hepatitis B virus infection

Autor: Toru Nishikawa, Naoto Kawabe, Kentaro Yoshioka, Senju Hashimoto, Naohiro Ichino, Masashi Ohki, Takuji Nakano, Tomoki Takamura, Aiko Fukui, Sayuri Nomura, Keisuke Osakabe, Takamitsu Kurashita, Yuka Ochi, Kazunori Nakaoka, Toshiki Kan, Michihito Murao
Rok vydání: 2016
Předmět:
Zdroj: Hepatology Research. 47:755-766
ISSN: 1386-6346
Popis: Aim Genome-wide association studies have revealed that single nucleotide polymorphism (SNP) of human leukocyte antigen (HLA)-DQ is associated with the clearance of hepatitis B surface antigen (HBsAg) in acute hepatitis B virus (HBV) infection. We examined the effects of the SNPs on the development of hepatocellular carcinoma (HCC) and markers of HBV in chronic HBV infection. Methods The SNPs of HLA-DQ (rs2856718 and rs7453920) were determined in 299 patients with chronic HBV infection. Results In 224 HBV envelope antigen (HBeAg)-negative patients, those with rs2856718 genotype AG + GG had significantly lower hepatitis B core-related antigen levels (p = 0.0184), less frequent treatment with nucleotide/nucleoside analogs (NAs) (p = 0.0433), and less frequent HCC development (p = 0.0256) than those with genotype AA. Multivariate analysis selected age (p = 0.0460), platelet (p = 0.0481), γ-GTP (p = 0.0030) and NAs treatment (p = 0.0003) as factors independently associated with HCC development. HBeAg-negative patients with rs7453920 genotype GG had significantly lower HBsAg levels (p
Databáze: OpenAIRE
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