Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b

Autor:	Guoying Qian, Ceri Weber, Chutian Ge, Jong Gwan Lee, Yingjie Zhou, Blanche Capel, Loren L. Looger
Rok vydání:	2020
Předmět:	Regulation of gene expression Multidisciplinary Mediator biology Chemistry Regulator Transcriptional regulation STAT protein biology.protein Phosphorylation STAT3 Psychological repression Cell biology
Zdroj:	Science. 368:303-306
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.aaz4165
Popis:	How egg temperature sets sex In many reptiles, sex is determined by nest temperature during egg incubation. Temperature regulates the expression of an epigenetic modifier gene called Kdm6b , which is responsible for testis development. However, the molecular connection between temperature and sex-specific expression of this factor was previously unknown. Weber et al. have identified a link between temperature and the activation of a key regulator of Kdm6b called signal transducer and activator of transcription 3 (STAT3). After an influx of Ca 2+ at the warmer, female-producing temperature, STAT3 is phosphorylated and silences Kdm6b transcription to repress testis development. Science , this issue p. 303
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5dd7e8a1dd4b06b712d4da883110a1e5 https://doi.org/10.1126/science.aaz4165 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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