Co2(CO)8 as a convenient in situ CO source for the direct synthesis of benzamides from aryl halides (Br/I) via aminocarbonylation

Autor:	Kuppanagounder P. Elango, Poongavanam Baburajan
Rok vydání:	2014
Předmět:	In situ chemistry.chemical_classification Aryl Aryl halide Organic Chemistry Halide Biochemistry Medicinal chemistry chemistry.chemical_compound chemistry Drug Discovery Functional group Nitro Benzamide Carbonylation
Zdroj:	Tetrahedron Letters. 55:1006-1010
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2013.12.062
Popis:	A fast, mild, and functional group tolerant method for the direct synthesis of benzamides from aryl halides (Br, I) via aminocarbonylation, using solid Co 2 (CO) 8 as a convenient CO source, has been demonstrated. The developed method is applicable to a wide variety of 1° and cyclic and acyclic 2° amines. Nitro substituted ( o, m and p ) aryl halides have easily been converted to the corresponding benzamides, without the reduction of the nitro group, in high yields using this in situ carbonylation methodology under microwave irradiation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5dd300c51cff573eac9b2b123097b761 https://doi.org/10.1016/j.tetlet.2013.12.062 Zobrazit plný text záznamu Full Text from ScienceDirect