Lipid Metabolism, Abdominal Adiposity, and Cerebral Health in the Amish
| Autor: | S. Andrea Wijtenburg, Joshua Chiappelli, Peter Kochunov, Alan R. Shuldiner, Laura M. Rowland, L. Elliot Hong, Heather Bruce, Jeffrey R. O'Connell, Xiaoming Du, Feven Fisseha, Els Fieremans, Seth A. Ament, Meghann C. Ryan, Jelle Veraart, Braxton D. Mitchell, Bhim M. Adhikari, Dmitry S. Novikov, Hemalatha Sampath |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Blood lipids 030204 cardiovascular system & hematology White matter 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Fractional anisotropy medicine 10. No inequality Nutrition and Dietetics Triglyceride business.industry Cholesterol Lipid metabolism medicine.disease Obesity medicine.anatomical_structure chemistry Old Order Amish business 030217 neurology & neurosurgery |
| Zdroj: | Obesity. 25:1876-1880 |
| ISSN: | 1930-7381 |
| Popis: | Objective To assess the association between peripheral lipid/fat profiles and cerebral gray matter (GM) and white matter (WM) in healthy Old Order Amish (OOA). Methods Blood lipids, abdominal adiposity, liver lipid contents, and cerebral microstructure were assessed in OOA (N = 64, 31 males/33 females, ages 18-77). Orthogonal factors were extracted from lipid and imaging adiposity measures. GM assessment used the Human Connectome Project protocol to measure whole-brain average cortical thickness. Diffusion-weighted imaging was used to derive WM fractional anisotropy and kurtosis anisotropy measurements. Results Lipid/fat measures were captured by three orthogonal factors explaining 80% of the variance. Factor one loaded on cholesterol and/or low-density lipoprotein cholesterol measurements; factor two loaded on triglyceride/liver measurements; and factor three loaded on abdominal fat measurements. A two-stage regression including age/sex (first stage) and the three factors (second stage) examined the peripheral lipid/fat effects. Factors two and three significantly contributed to WM measures after Bonferroni corrections (P |
| Databáze: | OpenAIRE |
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